RNA Details
Disease Name
diabetic cardiomyopathy
Tissue
heart
RNA Symbol
mir-133a-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; Masson's trichrome staining etc.
Target
SMAD2
Pathway
MAPK SIGNALING PATHWAY
PubMed ID
Title
Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes
Year
2014
Function
"A drastic decrease in miR-133a expression in the hearts of streptozotocin-induced diabetic animals and this decrease was accompanied by an increase in the transcriptional co-activator EP300 mRNA and major markers of fibrosis [transforming growth factor-beta1, connective tissue growth factor, fibronectin (fn1) and COL14A1]."